Phenol, 3-[(1S)-1-(dimethylamino)ethyl]-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Principles of method if other than guideline:

Organisation for Economic Co-operation and Development
(OECD), OECD Guidelines for Testing of Chemicals, Section 4,
Health Effects, No. 402, "Acute Dermal Toxicity", Paris
Cedex, 1987.


European Community (EC), Council Directive 67/548/EEC, Annex
V, Part B, Methods for the determination of Toxicity, as
last amended by Commission Directive 92/69/EEC, B.3: "Acute
Toxicity (Dermal)". Official Journal of the European
Communities No. L 383, 1992.


United States Environmental Protection Agency (EPA). Health
Effects Test Guidelines, OPPTS 870.1200, Acute Dermal
Toxicity. Office of Prevention, Pesticides and Toxic
Substances (7101), EPA 712-C-96-192, August 1998.


Japanese Ministry of Agriculture, Forestry and Fisheries
(JMAFF), 12 Nousan, Notification No 8147, November 2000;
including the most recent partial revisions.

GLP compliance:

yes

Limit test:

yes

Test animals

Species:

other: Rat, Wistar strain, Crl:WI (Han)

Administration / exposure

Type of coverage:

occlusive

Vehicle:

propylene glycol

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: Piloerection and/or chromodacryorrhoea (snout) were noted among the animals on Day 1. No mortality occurred. Body weight loss was seen in all males and in 3/5 females during the first week of the stud

Gross pathology:

Effects on organs:
No abnormalities were found at macroscopic post mortem
examination of the animals.

Other findings:

Signs of toxicity (local):
Scales and/or scabs were seen in the treated skin-area of
the majority of animals during the observation period.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU