Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 414-490-2 | CAS number: 154212-59-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two key in-vitro genotoxic experimental studies, Ames and chromosome aberration study, have been completed. One in-vivo study, mouse micronucleus study with reliability assigned a 1 has been completed.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No dose-related and reproducible increases in revertant colony frequency were observed in any tester strains at any concentration, both with and without S9. The test substance was not genotoxic in the Ames test.
Chromosome Aberrations in Purified Human Lymphocytes: with and without exogenous metabolic activation with a confirmatory assay with multiple harvests. The test article is considered equivocal for inducing chromosomal aberrations under conditions of metabolic activation at extremely toxic dose levels and not clastogenic without metabolic activation.
Mouse Micronmucleus study: Test substance was considered non-clastogenic in this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
