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EC number: 700-263-8 | CAS number: 89686-69-1
Table 1: Individual eye irritation scores.
Time after dosing
Fluor area (%)2
1Sentinel,2Green staining after fluorescein treatment (percentage of total corneal area)
Comments:gSlight dulling of the normal luster of the cornea.
In a study performed according to OECD 405 test guidelines, instillation of 0.1 mL of Ditetrahydrofurylpropane into one eye of each of three rabbits resulted in effects on the cornea, iris and conjunctivae. The corneal injury consisted of opacity (maximum grade 1 or 2) and epithelial damage (maximum 65, 50 or 25% of the corneal area). The corneal injury had resolved within 72 hours in one animal and within 7 days in the other two animals. Iridial irritation grade 1 was observed and had resolved within 24 or 72 hours or within 7 days. The irritation of the conjunctivae consisted of redness, chemosis and discharge and had completely resolved within 14 days in all animals. There was no evidence of ocular corrosion. No staining of (peri) ocular tissues by the test substance was observed and no test substance remnants were seen. No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. Based on these effects the test substance is classified for eye irritation Category 2 according to CLP Regulation (EC) 1272/2008.
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