Registration Dossier

Environmental fate & pathways

Adsorption / desorption

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 March - 15 May, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study has been performed according to OECD and/or EU guidelines and according to GLP principles.
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC estimation method
Media:
sewage sludge
Radiolabelling:
no
Test temperature:
35°C
Details on study design: HPLC method:
According to the guidelines, the estimation of the Koc for test substances that are ionized for at least 10% within pH 5.5 to 7.5 should be performed with both the ionized and non-ionized form. Therefore, the pKa values of the test substance were calculated using the Perrin calculation method (pKalc 5.0, module in Pallas 3.0, CompuDrug International San Francisco, CA, USA). Based on the calculations (pKa -2.93 and -3.54), it was decided to perform the HPLC analysis at neutral pH.

Analytical conditions:
Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
Detector: Refractive index detector 2414 (Waters)
Column: 150 mm x 4.6 mm i.d. Hypersil BDS-CN; dp = 5 µm (Thermo, San Jose, CA, USA)
Column temperature: 35 +/- 0.5°C
Mobile phase: 40/60 (v/v) methanol/Milli-Q water
Flow: 1 ml/min
Injection volume: 10 µl
RI detection: Sensitivity 64; time constant 1 second; temperature 35°C

A 3730 mg/l stock solution of the test substance was prepared in mobile phase.
The test substance blank solution was mobile phase.
The reference substance- and test substance solutions were injected in duplicate. Blank solutions were analysed by single injection.
Key result
Type:
Koc
Value:
62 L/kg
Temp.:
20 °C
Key result
Type:
log Koc
Value:
1.79 dimensionless
Temp.:
20 °C
Details on results (HPLC method):
In the chromatogram of the test substance solution, one test substance peak was observed. The peaks at 2.2 and 5.4 minutes was also observed in the chromatogram of the blank solution. Therefore, it was assumed that these compounds did not derive from the test substance.
Validity criteria fulfilled:
yes
Conclusions:
The Koc and log Koc values of Ditetrahydrofurylpropane at neutral pH are: 62 and 1.79, respectively.

Description of key information

A study was conducted according to OECD guideline 121.

Key value for chemical safety assessment

Koc at 20 °C:
62

Additional information

[LogKoc: 1.79]