Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1992

Materials and methods

GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals / tissue source

Species:
rabbit

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 15 min
Remarks on result:
other: mild conjunctival redness and discharge
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 2 h
Reversibility:
fully reversible within: 4 days
Remarks on result:
other: mild chemosis
Irritation parameter:
overall irritation score
Time point:
other: 24h
Reversibility:
fully reversible within: 4 days
Remarks on result:
other: Mild conjunctival redness, chemosis and mild discharge
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48h
Reversibility:
fully reversible within: 4 days
Remarks on result:
other: Decrease of signs
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 4 days
Remarks on result:
other: All rabbits were normal

Any other information on results incl. tables

Minimally irritating to the eyes

Applicant's summary and conclusion