Registration Dossier
Registration Dossier
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EC number: 604-770-4 | CAS number: 151012-31-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- {1-[(4-bromophenyl)methyl]-2-butyl-4-chloro-1H-imidazol-5-yl}methanol
- EC Number:
- 604-770-4
- Cas Number:
- 151012-31-6
- Molecular formula:
- C15H18BrClN2O
- IUPAC Name:
- {1-[(4-bromophenyl)methyl]-2-butyl-4-chloro-1H-imidazol-5-yl}methanol
- Reference substance name:
- 700-016-4
- EC Number:
- 700-016-4
- IUPAC Name:
- 700-016-4
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 15 min
- Remarks on result:
- other: mild conjunctival redness and discharge
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 2 h
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: mild chemosis
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24h
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: Mild conjunctival redness, chemosis and mild discharge
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48h
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: Decrease of signs
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 days
- Remarks on result:
- other: All rabbits were normal
Any other information on results incl. tables
Minimally irritating to the eyes
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
