Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November December 2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
EC Number:
454-450-1
EC Name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
Cas Number:
429659-01-8
Molecular formula:
C18 H20 N4 O5
IUPAC Name:
ethyl 3-{1-[4-(methylamino)-3-nitrophenyl]-N-(pyridin-2-yl)formamido}propanoate
Test material form:
solid: particulate/powder
Radiolabelling:
no

Study design

Analytical monitoring:
not specified
Duration of test
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
100 µg/L
Positive controls:
no
Negative controls:
no

Results and discussion

Transformation products:
not specified
Dissipation DT50 of parent compoundopen allclose all
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0.004 h-1
DT50:
184 h
Type:
not specified
pH:
9
Temp.:
40 °C
Hydrolysis rate constant:
0.02 h-1
DT50:
34 h
Type:
not specified
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.06 h-1
DT50:
12 h
Type:
not specified

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
From the experimental data obtained it can be concluded that the abiotic degradation hydrolysis if BIBR 1048 Manamide is significant only at ph 9 (> 10% in 5 days at 50 °C).