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EC number: 427-650-1 | CAS number: -
SUMMARY TABLES AND STATISTICS
Test compound: Reaktiv Gelb BZK 5934
Number of animals
Poly / animal counted
Poly/Ery SD Mean
Poly with MN
Poly with MN [%]
Poly with MN SD
0 – Control
40 – Endoxan
Mut. I. = Mutagenic Index
Control = Vehicle (deionised water)
* = Significantly different from control (p < 0.05)
A cross comparison of individual data and pooled data may show discrepancies since the values are rounded.
The micronucleus test was carried out with Reaktiv Gelb BZK 5934 (Batch No. BZK5934). The test compound was suspended in deionised water and was given twice at an interval of 24 hours as oral doses of 2000 mg per kg body weight to male and female rats (Hsd:Sprague Dawley), based on the results of a previous dose range finding assay. Endoxan® was used as positive control substance and was administered once orally at a dose of 40 mg per kg body weight.
The number of polychromatic erythrocytes containing micronuclei in all dose groups was not significantly increased compared with the control. The ratio of polychromatic erythrocytes to total erythrocytes in both male and female animals remained unaffected by the treatment with Reaktiv Gelb BZK 5934 and differed less than 20% from the control value.
Endoxan® induced a marked statistically significant increase in the number of polychromatic cells with micronuclei, indicating the sensitivity of the test system. The ratio of polychromatic erythrocytes to total erythrocytes was not changed to a significant extent.
Under the conditions of the present study the results indicate that Reaktiv Gelb BZK 5934 is not clastogenic in the micronucleus test in vivo.
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