Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report Date:
1996

Materials and methods

Test guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): 625-Triketon
Analytical purity: 99.4g/100g
Lot/batch No.: LJ 27881/1

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.1
Temp.:
25 °C
pH:
5.32

Any other information on results incl. tables

From thelistedlog k '/ logPowvalue pairs ofreference substances results in the followingfunctional equation:
log Pow=4.17* logk'+2.31
Correlation coefficient r =0.9776
By means of the functional equationis calculated for 625-triketonefollowing log Powvalue:
log Pow=4.10

The calculated value of the logPow resulted in 1.734

Applicant's summary and conclusion