Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report Date:
1996

Materials and methods

Test guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. certificate)
Type of method:
thermal analysis

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): 625-Triketon
Analytical purity: 99.4g/100g
Lot/batch No.: LJ 27881/1

Results and discussion

Melting / freezing pointopen allclose all
Melting / freezing pt.:
73.6 °C
Atm. press.:
1 013 hPa
Remarks on result:
other: modification of the delivery state
Melting / freezing pt.:
57.5 °C
Atm. press.:
1 013 hPa
Remarks on result:
other: after the first melting and solidification

Any other information on results incl. tables

DSC results:
Lets you freeze the sample after the first melting and then heats up again, then there is the second melting point of about 16 °C lower. Re-solidification and heating does not change anything more. Therefore the substance after the first melting and solidification is in another modification as when delivered.

Both temperatures are given (1.Run / 2. Run).

Melting temperature (extrapolated onset temperature)

   1. Run  2. Run
1. Measurement    + 73,1 °C + 56,9 °C 
2. Measurement    + 74,2 °C  + 57,8 °C
3. Measurement    + 73,8 °C  + 57,7 °C
4. Measurement    + 73,1 °C  + 57,7 °C

Summary:

73.6 °C (modification of the delivery state) and 57.5 °C (further modification in which the modification of the delivery condition
by melting and solidification converts); each ± 0.6 ° C measurement inaccuracy (See test results in detail. )

Applicant's summary and conclusion