Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference Type:
other: Body responsible for the test

Materials and methods

Test guideline
according to guideline
other: 92/69/EWG, B.3; OECD 402 (1987)
GLP compliance:
Limit test:

Test animals

other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:
other: Wasser "ENGLISH" Water
Duration of exposure:
24 h

Results and discussion

Effect levels
Dose descriptor:
Effect level:
> 2 000 mg/kg bw
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Keine behandlungsbedingten makroskopischen pathologischen Befunde bei den am Versuchsende getöteten Tieren. "ENGLISH" No treatment-related macroscopic pathological findings in the animals killed at the en
Gross pathology:
Effects on organs:
Es wurden keine behandlungsbedingten Effekte beobachtet.


No treatment-related effects were observed.
Other findings:
Signs of toxicity (local):
Keine klinischen Symptome bei den männlichen und weiblichen
Tieren. Leicht reduzierte Körpergewichte an Tag 8 und

Tag 15 bei jeweils einer weiblichen Ratte sind dem Stress
der Applikation zuzuschreiben. Die Körpergewichtsentwick-
lung war ansonsten bei Männchen und Weibchen unbeeinflusst.


No clinical symptoms in the male and female animals. The
slgihtly reduced body weights on day 8 and day 15 in one
female animal in each case are to be ascribed to the stress
of the application. Otherwise, there was no influence on the
body-weight gain of the male and female animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU