Registration Dossier
Registration Dossier
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EC number: 458-660-4 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.3; OECD 402 (1987)
- GLP compliance:
- yes
- Limit test:
- yes
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Wasser "ENGLISH" Water
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Keine behandlungsbedingten makroskopischen pathologischen Befunde bei den am Versuchsende getöteten Tieren. "ENGLISH" No treatment-related macroscopic pathological findings in the animals killed at the en
- Gross pathology:
- Effects on organs:
Es wurden keine behandlungsbedingten Effekte beobachtet.
"ENGLISH"
No treatment-related effects were observed. - Other findings:
- Signs of toxicity (local):
Keine klinischen Symptome bei den männlichen und weiblichen
Tieren. Leicht reduzierte Körpergewichte an Tag 8 und
Tag 15 bei jeweils einer weiblichen Ratte sind dem Stress
der Applikation zuzuschreiben. Die Körpergewichtsentwick-
lung war ansonsten bei Männchen und Weibchen unbeeinflusst.
"ENGLISH"
No clinical symptoms in the male and female animals. The
slgihtly reduced body weights on day 8 and day 15 in one
female animal in each case are to be ascribed to the stress
of the application. Otherwise, there was no influence on the
body-weight gain of the male and female animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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