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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD guideline study conducted according to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Crl:(WI)BR
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
300 and 2000 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 300 - < 2 000 mg/kg bw
Based on:
act. ingr.
Mortality:
2000 mg/kg b.w.: all animals died on the day of the administration
Gross pathology:
An abnormal finding, namely a systolic heart arrest, was present only in deceased animals (2000 mg/kg bw).
All other animals were normal at the necropsy 14 d.
Other findings:
All animals were affected after administation.
The findings, with an onset shortly after the administration and lasting until death or to a
maximum of 6 h were:
Central nervous effects: clonic convulsions. Signs of reduced well-being. This term encompasses unspecific alterations, like sedation,
apathy, piloerection, hunched posture or closed eyes, in single or multiple occurrence.

Applicant's summary and conclusion

Conclusions:
According to the GHS (Globally Harmonised System) the test substance "rac-1-(3-Methoxyphenyl)ethylamine" should be classified in the hazard category 4 (LD50 value in the range of 300 - 2000 mg per kg body weight).