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EC number: 695-977-9 | CAS number: 1309955-79-0
Summary of dermal irritation (following 4-h application)
Days after application
Mean score erythema
Mean score oedema
Mean all animals
? Unable to evaluate degree of erythema or oedema due to presence of other adverse dermal reactions
At day 7: scabs, dry straw-coloured crust, sometimes flaking from the skin (possible hyperkeratinisation)
At day 14: desquamation, thickening of the skin, scabs, scar tissue, reduced re-growth of fur, skin glossy in appearance (keratinolysis)
A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method used followed the recommendations of the OECD Guidelines for Testing of Chemicals No. 404 "Acute Dermal Irri tation/Corrosion" and Method B4 of the EC. A single
4 -hour, semi-occluded application of the test material to the intact skin of six rabbits produced severe dermal responses. Scar tissue, indicative of dermal corrosion was noted in 5 out of 6 rabbits 14 days after application. The test material was therefore classified as corrosive (Category 1C) to the rabbit skin, according to OECD/GHS criteria.
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