Registration Dossier
Registration Dossier
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EC number: 609-106-7 | CAS number: 35249-89-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
The available data demonstrate that alfa-hydroxyacid ingredients can be dermal irritants. Available data show an interdependence of concentration and pH. At a given pH, increasing the concentration increases irritation. At a given concentration, reducing the pH increases the irritation. The extensive data on irritation produced by alfa-hydroxyacid ingredients suggest that concentrations of Glycolic Acid used in leave-on products no greater than 20% and Lactic Acid no greater than l0%, with a pH no less than 3.5, would not produce irritation to an unacceptable degree. Likewise, rinse-off uses with concentrations no greater than 30% and a pH no less than 3.0 are considered to present an acceptable irritation risk if applied in a brief, discontinuous fashion followed by thorough rinsing by trained individuals (CIR, 1998).The available data indicate that pH is the most important factor affecting the irritancy of alfa-hydroxyacid products and is more important than concentration (SCCS, 2004).
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
According to a grouping approach and basing on the available data, ammonium glycolate is expected to be irritant to the skin if applied undiluted and therefore it is classified according to Regulation (EC) n. 1272/2008 as follows:
Skin Irrit. 2, H315
Eye Irrit. 2, H319
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