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EC number: 800-991-7 | CAS number: 1427388-03-1
Main study Six concentrations ranging from 31.6 to 5000 μg V125226/plate were employed in the plate incorporation test and in the preincubation test, each carried out without and with metabolic activation.
Test item precipitation was noted in the plate incorporation test and in the preincubation test, each carried out without and with metabolic activation at the top concentration of 5000 μg V125226/plate in all test strains. In addition, cytotoxicity was noted in the plate incorporation test without and with metabolic activation at the top concentration of 5000 μg V125226/plate in test strains TA98 and TA100 or TA100, respectively, and in the preincubation test without and with metabolic activation in test strain TA1537. The reduction of the number of revertants by more than 50% in test strain TA1537 in the preincubation test without metabolic activation at 31.6 μg/plate is considered to be caused by the high variation in individual counts and not due to cytotoxicity.
No increase in revertant colony numbers as compared with control counts was observed for V125226, tested up to a concentration of 5000 μg/plate, that led to test item precipitation and, in addition, to cytotoxicity in some strains, in any of the 5 test strains in two independent experiments without and with metabolic activation, respectively (plate incorporation and preincubation test). The positive control items showed a significant increase in the number of revertant colonies of the respective test strain and confirmed the validity of the test conditions and the sensitivity of the test system.
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