Registration Dossier

Administrative data

First-aid measures

Ingestion:
Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation:
Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which may be delayed.

Skin contact:
Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of soap and water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eye contact:
Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

NOTES TO HEALTH PROFESSIONALS
Medical Treatment:
Treat according to locally accepted protocols. For additional guidance, refer to the local poison control information centre. In allergic individuals, exposure to this material may require treatment for initial or delayed allergic symptoms and signs. This may include immediate and/or delayed treatment of anaphylactic reactions.

Medical Conditions Caused or Aggravated by Exposure:
Ocular symptoms may be indicative of allergic reaction.

Health Surveillance Procedures:
Pre-placement and periodic health surveillance is not usually indicated. The final determination of the need for health surveillance should be determined by local risk assessment. Exposed individuals are encouraged to report symptoms of skin and respiratory irritation to an occupational health professional or line management. These symptoms may include, but are not limited to, skin conditions, bronchitis, asthma, or nasal irritation.

Antidotes:
No specific antidotes are recommended.

Fire-fighting measures

Fire and Explosion Hazards:
The flammability of this material has not been determined.
As with many organic dusts, explosions can occur if this material is dispersed as a dust cloud and ignited.

Suitable Extinguishing Media:
Water, dry powder or foam extinguishers are recommended. Carbon dioxide extinguishers may be ineffective.

Special Protective Equipment and Precautions for Firefighters:
Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.

Specific Hazards arising from the Material:
Toxic, corrosive or flammable thermal decomposition products, which might include fluorine compounds, are expected when the material is exposed to fire.

Accidental release measures

Personal Precautions:
Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.

Environmental Precautions:
Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.

Clean-up Methods:
Collect and place it in a suitable, properly labelled container for recovery or disposal. After all solid or absorbent material has been collected, the area should be vacuumed with HEPA filter-equipped apparatus.

Decontamination Procedures:
No specific decontamination or detoxification procedures have been identified for this material. Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and decontamination operations.

Handling and storage

General Requirements:
Avoid dispersion as a dust cloud.
Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion hazards during handling of this material.

Ignition Controls:
Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.

CONDITIONS FOR SAFE STORAGE
Keep in tightly closed containers or packages away from moisture and away from sources of ignition.
Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).

Transport information

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Marine transport (IMDG)

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Additional transport information

Additional transport information
Basic Shipping Description: Not regulated in transport.

Exposure controls / personal protection

OCCUPATIONAL EXPOSURE LIMITS

1. Technical protection measures
ENGINEERING CONTROLS
Exposure Controls:
The hygiene guide for this material is >10 to 100 mcg/m3. An Exposure Control Approach (ECA)
is established for operations involving this material based upon the OEL/Occupational Hazard
Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure
Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment:
Open handling is not recommended. Consider segregating operations, use of enclosures and sealed transfer systems.
Ventilation:
Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a means of removing material incidentally released.
Administrative:
Entry to the working area should be controlled. Doors with interlocks may be needed for materials airlocks and locker rooms. Only equipment and supplies necessary for job activities should be taken into working area.

2. Organisational protection measures
GSK Occupational Hazard Category: 3 PROVISIONAL

PERSONAL PROTECTIVE EQUIPMENT

1. Hand protection
Gloves:
The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be
sought from your local EHS department.

2. Eye protection
Eye Protection:
Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

3. Respiratory protection
Respirators:
If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as well as hazards, physical properties and warning properties of substances present.

4. Other Equipment or Procedures
Follow all local regulations if personal protective equipment (PPE) is used in the workplace. Consider control procedures for maintenance, cleaning and emergencies. Wear appropriate clothing to avoid skin contact. An eye wash station should be available.

Stability and reactivity

Conditions to Avoid:
Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.

Disposal considerations

Disposal Recommendations:
Collect for recycling or recovery if possible. The recommended method of disposal is incineration.
Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of material in a licenced commercial chemical incinerator.

Regulatory Requirements:
Observe all local and national regulations when disposing of this material.