Registration Dossier
Registration Dossier
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EC number: 412-440-4 | CAS number: 2725-22-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 405
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 412-440-4
- EC Name:
- -
- Cas Number:
- 2725-22-6
- Molecular formula:
- C33H39N3O2
- IUPAC Name:
- 2-(4,6-bis-(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(octyloxy)-phenol
- Details on test material:
- Nature of substance: powder
Constituent 1
Test animals / tissue source
- Species:
- other: New Zealand White Rabbits
Test system
- Amount / concentration applied:
- 100mg
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Score:
- 1.67
- Max. score:
- 1.67
- Remarks on result:
- other: Max. duration: 48h; Max.value at end of observation period:0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Score:
- 0.67
- Max. score:
- 0.67
- Remarks on result:
- other: Max. duration: 48h; Max.value at end of observation period:0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Score:
- 0.16
- Max. score:
- 0.16
- Remarks on result:
- other: Max. duration: 24h; Max.value at end of observation period:0
- Irritation parameter:
- iris score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0h; Max.value at end of observation period:0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 3 days
- Other effects:
- Conjunctival irritation including blisterine in all but one animal after test article administration.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
