Registration Dossier
Registration Dossier
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EC number: 500-024-6 | CAS number: 9016-45-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Environmental and Human Safety of Major Surfactants: Alcohol Ethoxylates and Alkylphenol Ethoxylates
- Author:
- Talmage, S.S.
- Year:
- 1 994
- Bibliographic source:
- The Soap and Detergent Association, Lewis Publishers, Boca Raton.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- NPE 2-30
- IUPAC Name:
- NPE 2-30
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 0.1 mL
Results and discussion
Any other information on results incl. tables
in an eye irritation study of undiluted NPE solution at a dose of 0.1 mL, NPE solution was applied to the conjunctival sacs of New Zealand White rabbits and symptoms were observed. NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation
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