Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Environmental and Human Safety of Major Surfactants: Alcohol Ethoxylates and Alkylphenol Ethoxylates
Author:
Talmage, S.S.
Year:
1994
Bibliographic source:
The Soap and Detergent Association, Lewis Publishers, Boca Raton.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
NPE 2-30
IUPAC Name:
NPE 2-30

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
0.1 mL

Results and discussion

Any other information on results incl. tables

in an eye irritation study of undiluted NPE solution at a dose of 0.1 mL, NPE solution was applied to the conjunctival sacs of New Zealand White rabbits and symptoms were observed. NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation

Applicant's summary and conclusion

Interpretation of results:
other: NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation