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Diss Factsheets
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EC number: 203-597-8 | CAS number: 108-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is not irritating to the skin (OECD TG 404, GLP).
The test substance is irritating to the eye (OECD TG 405, GLP).
Key value for chemical safety assessment
Additional information
Skin irritation:
A GLP guideline study (OECD TG 404) study for assessment of skin irritation of Dimethylmalonate is available. Three rabbits (Small white russian, Chbb: HM, SPF) were treated with the undiluted test substance for 4 h under semiocclusive conditions. Slight erythema (grade 1) was observed in all 3 animals 30 to 60 min after removal of the patch. These findings were fully reversible within 24 hours. The mean values (24, 48, and 72h) of erythema and edema were 0 for all animals. Thus, the test substance is not irritating to the skin.
Eye irritation:
A GLP guideline study (OECD TG 405) study for assessment of eye irritation of Dimethylmalonate is available. Three rabbits (Small white russian, Chbb: HM, SPF) were treated with 0.1 mL of the undiluted test substance for 24 h. Then the test substance was washed out. Corneal opacity was observed in all 3 animals (mean score 24, 48, 72 h: 1, 1.33, 1.67), but was fully reversible within 6 days. Iris mean score (24, 48, 72 h) was 1, 0.33, 0.67. Iris score was also fully reversible within 6 days. Conjunctivae mean score (24, 48, 72 h) was 2 for all animals, and was fully reversible within 8 days. Also chemosis scores were fully reversible within 8 days (mean scores 24, 48 , 72 h: 1.33, 1.33, 1.67). Thus, the test substance is irritating to the eye.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
- No classification required for skin and eye irritation.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):
- No classification required for skin irritation.
- The test substance is classified as an eye irritant, Cat. 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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