Registration Dossier

Administrative data

Description of key information

GLP guideline study (OECD TG 401, adopted 1987): LD50, oral, rat >2000 mg/kg bw.
GLP guideline study (OECD TG 402, adopted 1987): LD50, dermal, rat>2000 mg/kg bw.

Key value for chemical safety assessment

Additional information

Acute toxicity, oral route:

A GLP guideline study (OECD TG 401, adopted 1987) for assessment of oral toxicity of Dimethylmalonate is available. Five animals per sex (Bor: WISW (SPF Cpb) rats) were treated by gavage with a limit dose of 2000 mg/kg bw test substance. During observation period no mortality or clinical signs at all were observed. Thus an LD50 >2000 mg/kg bw was deduced.

Acute toxicity, inhalation route:

No data available.

Acute toxicity, dermal route:

A GLP guideline study (OECD TG 402, adopted 1987) for assessment of dermal toxicity of Dimethylmalonate is available. Five animals per sex (Bor: WISW (SPF Cpb) rats) were treated for 24 hours with a semiocclusive dressing with a limit dose of 2000 mg/kg bw test substance. During observation period no mortality, clinical signs or local irritancy were observed. Thus an LD50 >2000 mg/kg bw was deduced.

Justification for classification or non-classification

Dangerous Substance Directive (67/548/EEC)

-No classification required for acute toxicity

Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):

-Oral and dermal route: no classification required