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EC number: 619-496-0 | CAS number: 960404-59-5
BMS-587319 -03 was tested in an acute dermal toxicity study with male and female rats, performed according to OECD 402 test guideline and GLP principles.
No mortality occurred. Due to the loss of the bandage, 2 females and 2 males were exposed to the test item for at least 5 hours and maximally 22 hours. Erythema, scabs and/or scales were noted on treated skin and/or flank of most of the animals exposed for 24 hours. One female showed a scar on the left flank. Among the animals exposed for 5-22 hours, similar skin effects were noted, however at lower severity. One female showed chromodacryorrhea on the day of exposure.
Reddish discolouration of the thymus, pale discolouration of the lung and/or pelvic dilation in the kidney were found at macroscopic post mortem examination in two animals exposed for 24 hours. Reddish discolouration of the thymus was also noted in two animals exposed for 5-22 hours. At the incidence observed this was considered not toxicologically significant.
Based on the results, an LD50 >2000 mg/kg bw was determined and BMS-587319 -03 does not have to be classified for acute dermal toxicity, according to Regulation (EC) No 1272/2008 on classification, labelling and packaging.
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