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Environmental fate & pathways

Adsorption / desorption

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Description of key information

The study was performed in accordance with EC C.9 and OECD 121 and according to the principles of GLP. No deviations were noted 
Using the HPLC method using soil-adsorption-reference data, the log Koc for the substance was determined to be 2.80 (Koc is 6.3E02).

Key value for chemical safety assessment

Koc at 20 °C:
630

Additional information

The HPLC estimation method was used for the determination of the adsorption coefficient (Koc) of BMS-587319-03. The HPLC chromatogram of the test substance solution showed one test substance peak. Using soil-adsorption reference data, the log Koc value was calculated to be 2.80 (Koc = 6.3E02). The mobile phase was 55/45 (v/v) methanol/water. The stationary phase contained cyanopropyl chains chemically bonded to silica. The column temperature was 35°C. The study was performed in accordance with EC C.9 and OECD 121 and according to the principles of GLP.

[LogKoc: 2.8]