Registration Dossier
Registration Dossier
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EC number: 412-440-4 | CAS number: 2725-22-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 405
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 412-440-4
- EC Name:
- -
- Cas Number:
- 2725-22-6
- Molecular formula:
- C33H39N3O2
- IUPAC Name:
- 2-(4,6-bis-(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(octyloxy)-phenol
- Details on test material:
- Nature of substance: powder
Constituent 1
Test animals / tissue source
- Species:
- other: New Zealand White Rabbits
Test system
- Amount / concentration applied:
- 100mg
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Score:
- 1.67
- Max. score:
- 1.67
- Remarks on result:
- other: Max. duration: 48h; Max.value at end of observation period:0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Score:
- 0.67
- Max. score:
- 0.67
- Remarks on result:
- other: Max. duration: 48h; Max.value at end of observation period:0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Score:
- 0.16
- Max. score:
- 0.16
- Remarks on result:
- other: Max. duration: 24h; Max.value at end of observation period:0
- Irritation parameter:
- iris score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0h; Max.value at end of observation period:0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 3 days
- Other effects:
- Conjunctival irritation including blisterine in all but one animal after test article administration.
Applicant's summary and conclusion
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