Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-643-2 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: Based on category approach.
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Category is coherent for more than 10 endpoints. Skin sensitiser category approach is notbly based on a clearly negative LLNA study on APP-6505.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Principles of method if other than guideline:
- Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and grouping of chemicals - ECHA, May 2008.
- GLP compliance:
- no
- Remarks:
- Not relevant for category approach.
- Type of study:
- other: LLNA and other data were used in the category approach.
Test material
- Reference substance name:
- D-pentose, oligomeric, C14 and C18 alkyl glycosides
- EC Number:
- 940-643-2
- IUPAC Name:
- D-pentose, oligomeric, C14 and C18 alkyl glycosides
Constituent 1
Results and discussion
Any other information on results incl. tables
The category approach is notably based on the substance that may potentially exhibit higher sensitisation and that showed stimulation indices only around 1.0 in a LLNA test (reliabiity 1, GLP). The APP category is clearly not skin sensitiser.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on read-across within the APP category and other arguments (comparison with other alkyl polyglycosides, absence of reactivity with amino-acids and proteins), it can be concluded with confidence that APP-6781 is not a skin sensitiser (see category approach report).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
