Registration Dossier
Registration Dossier
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EC number: 940-643-2 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No deviation from OECD-423 guideline and GLP. APP-6748 (C14-18) can be considered in the APP category as between (see APP category report) this C12-14 APP and the C16-18 (see also IUCLID dossier of APP-6669).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP Certificate as an annexe in the study report.
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Agrisurfactant S1726 (alkylpolypentoside C12-14)
- IUPAC Name:
- Agrisurfactant S1726 (alkylpolypentoside C12-14)
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 6 animals per sex per dose.
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No mortality occured during the study with an alkylpolypentosides C12-14, LD50 of APPyclean-6548 (APP C14-18) can be considered as higher than 2000 mg/kg bw by oral route in rat.
- Executive summary:
No mortality occured during the study with an alkylpolypentoside C12-14. No clinical signs related to administration of the test product were observed. The body weight evolution remained normal througout the study, similar between treated and control animals. The macroscopical examination at the end of the study did not reveal treatment-related changes. The LD50 of APPyclean-6548 (C14-18) can be considered as higher than 2000 mg/kg bw by oral route in the rat. No classification is needed. Please see full details about the absence of rat oral acute toxicity of alkylpolypentosides in APP category report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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