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EC number: 700-853-5
CAS number: 943586-12-7
PC2414 did not have eye and skin irritation potential nor any skin corrosion potential using the EPISKIN and HCE in vitro screening models.
Initially, a DEREK prediction of PC2414 did not indicate any
toxicological effects including eye and skin irritation/corrosion (see
attached document below), indicating the need for a tiered testing
The eye irritation potential of PC2424 was determined using the in vitro
SkinEthic Reconstituted Human Corneal model (HCE, SkinEthic
Laboratories, Nice, France). This type of study, although not yet
formally validated or adopted by regulatory authorities was part of a
tiered testing strategy for determining eye irritation at the lower end
of irritancy. PC2414 was shown not to be non-irritating to eye.
PC2414 was found to be non-corrosive and non-irritating to skin and eye
using the EPISKIN and HCE in vitro screening models. Based on these
result, PC2414 is not hazardous and is not classified according to GHS
and DSD-DPD and in accordance to the criteria in Council Directive
67/548/EEC and Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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