Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 606-239-2 | CAS number: 19130-96-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well reported GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
- EC Number:
- 606-239-2
- Cas Number:
- 19130-96-2
- Molecular formula:
- C6 H13 N O4
- IUPAC Name:
- (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
- Details on test material:
- Desoxynojirimycin, solid white to beige powder, content 97.2%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
Results of the study
| Irritant Effects (Score) | |||||
| Animal | 24 h | 48 h | 72 h | Mean scores | |
| 1 | Corneal Opacity | 0 | 0 | 0 | 0.0 |
| Iritis | 0 | 0 | 0 | 0.0 | |
| Redness conjunctivae | 0 | 0 | 0 | 0.0 | |
| Chemosis conjunctivae | 0 | 0 | 0 | 0.0 | |
| Fluorescein | negative | negative | negative | ||
| 2 | Corneal Opacity | 0 | 0 | 0 | 0.0 |
| Iritis | 0 | 0 | 0 | 0.0 | |
| Redness conjunctivae | 0 | 0 | 0 | 0.0 | |
| Chemosis conjunctivae | 0 | 0 | 0 | 0.0 | |
| Fluorescein | negative | negative | negative | ||
| 3 | Corneal Opacity | 0 | 0 | 0 | 0.0 |
| Iritis | 0 | 0 | 0 | 0.0 | |
| Redness conjunctivae | 0 | 0 | 0 | 0.0 | |
| Chemosis conjunctivae | 0 | 0 | 0 | 0.0 | |
| Fluorescein | negative | negative | negative | ||
Applicant's summary and conclusion
- Executive summary:
80 mg of the test substance was administered into the conjunctival sac of in each case one rabbit eye of 3 females and after 24 h the treated eyes were rinsed with physiologic saline.
Evaluation of eye irritation was made according to Draize.
According to the classification criteria Desoxynojirimycin is not irritating to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
