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EC number: 309-665-4 | CAS number: 100683-96-3
+ = present
h = hour (s)
' = minute
Frequency of observation = number of occurence of observation / total number of observations
BODY WEIGHT DATA
Body weight (g) days
The single-dose oral toxicity of Carbohydrates and Sugars, hexitols, anhydro - LAB 4623 was performed according to the acute toxic class method (OECD 423 and Commission Regulation (EC) No 440/2008 of 30 May 2008, B.1.Tris) in CRL:(WI) rats. Two groups of three female CRL:(WI) rats were treated with the test item at a dose level of 2000 mg/kg bw (Group 1 and Group 2). A single oral treatment was carried out by gavage for each animal after an overnight food withdrawal. Food was made available again 3 hours after the treatment. The test item was administered formulated in distilled water at a concentration of 200 mg/mL at a dosing volume of 10 mL/kg bw. Initially, three females (Group 1) were treated at a dose level of 2000 mg/kg bw. As no mortality was observed, a confirmatory group (Group 2) was treated at the same dose level. No mortality was observed in the confirmatory group, therefore no further testing was required according to OECD 423 and Commission Regulation (EC) NO 440/2008 of 30 May 2008, B.1.Tris. Clinical observations were performed at 30 minutes, 1, 2, 3, 4 and 6 hours after dosing and daily for 14 days thereafter. Body weight was measured on Days -1, 0 and 7 and before necropsy. All animals were subjected to a necropsy and a macroscopic examination. Carbohydrates and Sugars, hexitols, anhydro - LAB 4623 did not cause mortality at a dose level of 2000 mg/kg bw. Treatment with Carbohydrates and Sugars, hexitols, anhydro - LAB 4623 at the dose level of 2000 mg/kg bw did not cause any systemic clinical signs after the treatment until the end of the observation period. Body weight gains of Carbohydrates and Sugars, hexitols, anhydro - LAB 4623 treated animals during the study showed no indication of a test item-related effect. No macroscopic changes were observed at necropsy on Day 14. Under the conditions of this study, the acute oral LD50 value of the test item Carbohydrates and Sugars, hexitols, anhydro - LAB 4623 was found to be above 2000 mg/kg bw in female CRL:(WI) rats.
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