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EC number: 433-930-4 | CAS number: -
Test substance concentrations selected for the main study were based on the results of a preliminary study. In the main study, ten experimental animals were intradermally injected with a 10% concentration and epidermally exposed to a 50% concentration. Five control animals were similarly treated, but with vehicle alone (propylene glycol). Approximately 24 hours before the epidermal induction exposure all animals were treated with 10% SDS.
Two weeks after the epidermal application all animals were challenged with a 50% test substance concentration and the vehicle.
No skin reactions were evident after the challenge exposure in the experimental and control animals. Red staining was observed at the test substance treated skin sites, 24 and 48 hours after challenge. This staining did not hamper the scoring of the skin reactions.
There was no evidence that TKP 50048 had caused skin hypersensitivity in the guinea pig, since no responses were observed in the experimental animals in the challenge phase.
This result indicates a sensitisation rate of 0 per cent.
Based on these results and according to the EC criteria for classification and labelling requirements for dangerous substances and preparations (Guidelines in Commission Directive 93/21/EEC), TKP 50048 does not have to be classified and has no obligatory labelling requirement for sensitisation by skin contact.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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