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EC number: 433-930-4 | CAS number: -
Single samples of approximately 28 mg of TKP 50048 (a volume of approximately 0.1 ml) were instilled into one eye of each of three rabbits. Observations were made 1, 24, 48 and 72 hours after instillation.
Instillation of the test substance resulted in irritation of the conjunctivae, which was seen as redness and discharge. The irritation had completely resolved within 24 hours in two animals and within 48 hours in the other animal. Red staining of the fur on the head and paws, caused by the test substance, was noted throughout the observation period. Remnants of the test substance were present in the eyes of all animals on day 1 and on the outside of the eyelids of all animals on day 2.
Based on these results TKP 50048 induces minor eye irritation.
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