Registration Dossier

Administrative data

Endpoint:
carcinogenicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Carcinogenic and Toxicological Effects of Inhaled Ethylene Oxide and Propylene Oxide in F344 Rats.
Author:
Lynch, D.W., T.R. Lewis, W.J. Moorman, J.R. Burg, D.H. Groth, A. Khan, L.J. Ackerman and B.Y. Cockerell
Year:
1984
Bibliographic source:
Toxicol. Appl. Pharmacol. 76: 69-84

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 451 (Carcinogenicity Studies)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Mammary
Mortality:
mortality observed, treatment-related
Description (incidence):
Mammary

Effect levels

Dose descriptor:
LOAEL
Effect level:
300 ppm
Based on:
other: air concentration
Remarks on result:
other: Effect type: carcinogenicity (migrated information)

Applicant's summary and conclusion