Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats
Author:
Eldridge SR, Bogdanffy MS, Jokinen MP, Andrews LS
Year:
1995
Bibliographic source:
Fundam Appl Toxicol 27(1):25-32

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation

Results and discussion

Effect levels

Dose descriptor:
LOEC
Effect level:
362 mg/m³ air (nominal)
Based on:
other: olfactory cell proliferation

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion