Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The toxicity of inhaled ethylene oxide and propylene oxide vapors; acute and chronic toxicity of ethylene oxide and acute toxicity of propylene oxide
Author:
Jacobson KH, Hackley WB, Feinsilver L.
Year:
1956
Bibliographic source:
AMA Arch Ind Health 13(3):237-44

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
4 124 mg/m³ air
Based on:
test mat.

Applicant's summary and conclusion