Registration Dossier
Registration Dossier
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EC number: 700-287-9 | CAS number: 877179-04-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-amine
- EC Number:
- 700-287-9
- Cas Number:
- 877179-04-9
- Molecular formula:
- C12H8Cl2FN
- IUPAC Name:
- 3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-amine
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: viability
- Time point:
- other: 3 Min.
- Remarks on result:
- other: 96.32%
- Irritation parameter:
- other: viability
- Time point:
- other: 60 Min.
- Remarks on result:
- other: 107.80%
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Executive summary:
The test substance was not characterised by a significant impact on cell viability after the 3 min. and after the 60 min. period.
Thus, the test substance should not be labelled as corrosive to skin.
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