Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 425-220-8 | CAS number: 5945-33-5
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study planned
- Study period:
- Nov. 1 2011 to Feb 1 2012
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 425-220-8
- EC Name:
- -
- Cas Number:
- 5945-33-5
- Molecular formula:
- C39H34O8P2
- IUPAC Name:
- (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
- Details on test material:
- Same with the substance notified in the section 1 of this dossier
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Firstly, 1 g BDP is weighed by electric balance and then dissolved with dimethylformamide in 50 ml flask to get 20 g/l liquor. After that, 400,160,64 and 25.6 µL liquor is transferred into the 1 L flasks,repectively,and dissolved with M4 medium to get the 8,3.2,1.28 and 0.512mg/l test solution.
25.6,10.24 and 4.096 ml solution taking from the 8 mg/l test solution is transferred into the 1L flasks,repectively,and dissolved with M4 medium to get the 0.205,0.082 and 0.033 test solution.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Obey with the OECD guideline 211.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- The fully defined medium M4 media(see SOP EX015) is used in the laboratory.
- Test temperature:
- 20±1°C
- pH:
- 7.8±0.2
- Dissolved oxygen:
- The dissolved oxygen concentration should be above 3 mg/l. In order to meet criteria, the test vessels should be aerated for 6 hours before the culture.
- Salinity:
- The fully defined medium M4 media (see SOP EX015) is used in the laboratory.
- Nominal and measured concentrations:
- Nominal concertrations 5mg/l.
- Details on test conditions:
- Obey with the OECD guideline 211.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Applicant's summary and conclusion
- Executive summary:
According to Directive 67/548/EECandCommission Regulation (EC) No: 790/2009, classification for BDPasR53and asaquatic chronic category 4, respectively,isnot assuredbased on the available data on aquatic environment, because of the absence of chronic toxicity evidences. If the chronic toxicity NOECs > water solubility or > 1 mg/L，the classification of BDP as R53 oraquatic chronic category 4will be revised and abolished. Therefore, the long-term toxicity study on Daphnia needs to be proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
