Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
the study of hydrolysis of BDP
Year:
2000
Bibliographic source:
National Occupation Health and Safety Commission

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-220-8
EC Name:
-
Cas Number:
5945-33-5
Molecular formula:
C39H34O8P2
IUPAC Name:
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
Radiolabelling:
no

Study design

Analytical monitoring:
not specified
Details on sampling:
Incubating stoppered flasks containing(nominally) 0.25 mg/L in buffer solutions at PH 4,7 and 9 for 5 days.

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.

Any other information on results incl. tables

Hydrolytic degradation of the compound was studied as a function of pH by incubating stoppered flasks containing (nominally) 0.25 mg/LBDPin buffer solutions at50 ±andpH 4, 7 and 9 for 5 days. The concentration of the compound in the solutions was determined using HPLC at various times over the 5 day (120 hour) test period. Very little degradation was observed in any of the buffers over the 5 day test period, with the maximum loss of 5% of initial concentration observed in the pH 9 buffer.

Applicant's summary and conclusion

Conclusions:
The half life of hydrolytic degradation for BDP in 25 °C is greater than 1 year at environmental pH 4-9.
Executive summary:

Hydrolytic degradation of the compound was studied as a function of pH (Hogg A S, 1997) by incubating stoppered flasks containing (nominally) 0.25 mg/L in buffer solutions at pH 4, 7 and 9 for 5 days. The concentration of the compound in the solutions was determined using HPLC at various times over the 5 day (120 hour) test period. Very little degradation was observed in any of the buffers