Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

GLS-Silane is considered to be corrosive based on read across to the primary constituents in GLS-Silane.  Dichloro(methyl)silane is accepted as being corrosive to skin (key study: BRRC, 1981) and, implicity, damaging to eyes. Acute inhalation toxicity studies have shown that this substance is corrosive to the respiratory tract. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Two studies were available for skin irritation/corrosion, therefore the most reliable of these was selected as the key study. Both studies showed dichloro(methyl)silane to be corrosive to the skin. A further study showed this substance to be corrosive to eyes. Dichloro(methyl)silane makes up 20 -40% of GLS-Silane and thus was used for read across. In addition, two other substances contained in GLS-Silane [chloro(dimethyl)silane - CAS 1066 -35 -9 - in GLS-Silane at 10 - 20% and trichlorosilane - CAS 10025 -78 -2 - in GLS-Silane at 5 -15%] waived in vivo skin testing on the basis of known corrosivity. Thus, based on the weight of evidence, GLS-Silane is considered to be corrosive to the skin and eyes.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Dichloro(methyl)silane is labelled 'R35 Causes severe burns' and 'R37 Irritating to respiratory system' under Directive 67/548/EEC. Based on a weight-of evidence the proposed labelling according to Regulation 1272/2008 is 'Skin Corr. 1A', and hence 'H314: Causes severe skin burns and eye damage', and 'EUH071: Corrosive to the respiratory tract'. The serious damage to eyes is implicit for substances classified as Category 1 for skin corrosion.