Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Skin irritation in rabbits:  Not irritating
Eye irritation in rabbits: Not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

A skin irritation test (Pharmakon Europe, 2001) was conducted in 6 New Zealand hybris albino rabbits. The study was conducted according to OECED 404 guidelines and EU method B.4. No irritation was observed in any of the animals tested.

An eye irritation test (Pharmakon Europe, 2001) was conducted in 6 New Zealand White rabbits. The study was conducted according to OECD 405 guidelines and EU method B.5. No irritation was observed in any of the animals tested.

Justification for classification or non-classification

Skin and eye irritation tests were conducted on T-1540N, but both tests were negative for irritation. On this basis it is considered that T-1540N should not be classified as irritant to either skin or eyes.