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EC number: - | CAS number: -
OBJECTIVE: The acute oral toxicity of TFEE-5 (MTDID 21721, batch TFEE5-276/12/09-1) was evaluated in female Wistar rats.
METHODS: This study was performed in compliance with OECD GLP (1997). The study design was based on OECD 423 (2001), EC 440/2008, B1, USEPA OPPTS 870.1100 (2002) and JMAFF guidelines (2000) including the most recent partial versions. TFEE-5 was tested as received. Two groups (3 females each) received 2000 mg/kg TFEE-5 via oral gavage. The rats were observed immediately and at 2 and 4 hours postdose and then once daily for 14 days. Body weights were recorded pretest, weekly, and at termination. All animals were examined for gross pathology.
RESULTS: All animals survived. Hunched posture and/or piloerection were noted in all animals on Day 1. There were no abnormal body weight changes or necropsy findings in any animals.
CONCLUSION: Based on the results of this study, the acute oral LD50 of TFEE-5 in female rats was greater than 2000 mg/kg.
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