Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 1, 2010 - November 15, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, method not recommended

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
yes
Remarks:
method not recommended for substances of this nature
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
method not recommended for substances of this nature
Qualifier:
according to
Guideline:
other: OECD 113 (1981) Screening test for thermal stability and stability in air.
Deviations:
yes
GLP compliance:
yes (incl. certificate)
Type of method:
dynamic method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material (as cited in study report: TFEE-5
- Physical state: liquid
- Lot/batch no.: TFEE5-276/12/09-1
- Expiration date of the lot/batch: 31 December 2012
- Storage condition of test material: Room temperature in the dark under nitrogen

Results and discussion

Vapour pressure
Key result
Temp.:
20 °C
Vapour pressure:
0.02 hPa
Transition / decomposition
Key result
Transition / decomposition:
no

Any other information on results incl. tables

Temperature-Vapour pressure equilibria were measured at increasing and decreasing temperatures.

Results are given in the Table.

Table, Vapour pressure of TFEE-5 as a function of temperature

Temperature (°C)

Vapour pressure (hPa)

104.0

9.0

135.3

51.0

151.6

101.0

163.0

150.7

182.7

301.7

199.0

502.1

211.8

700.8

221.0

900.0

203.4

600.5

192.3

401.4

171.3

202.0

147.0

80.6

 

Results were plotted as 1/T (K) v. log VP (Fig. 2). Temperature-vapour pressure equilibria lie along the same line whether measured at increasing or decreasing temperatures, indicating that volatile components were not driven off during the increasing temperature phase of the test. The parameterized Antoine equation is:

log VP (hPa) = 8.12184 - (2161.94/[200 + T (°C)]), R-sq = 0.998

Extrapolated vapour pressures:

20 °C: 0.020 hPa

25 °C: 0.033 hPa

50 °C: 0.30 hPa

Applicant's summary and conclusion

Conclusions:
The vapour pressure of TFEE-5 at 20 °C is 0.020 hPa
Executive summary:

The vapour pressure of TFEE-5 was measured using a dynamic method according to EC No. 440/2008.A.4 and OECD TG104. The experimental apparatus was assembled from commercially-available components and calibrated regularly using n-Heptane and Hexadecane. Equilibrium data were analyzed using the Antoine relationship. The parameterized Antoine equation is log VP (hPa) = 8.12184 - (2161.94/[200 + T (°C)]) (R-sq = 0.998). The vapour pressure of TFEE-5 at 20 °C is 0.020 hPa.

The study was performed under GLP criteria and in accord with procedures detailed in internationally-accepted guidelines for the dynamic method. However, the dynamic method is not recommended for substances with VP less than 10 hPa. Therefore, the study is classified as reliable with restrictions.