Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 914-920-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Guideline study with acceptable restrictions (Only raw data were reported, information on substance identity and composition is lacking and no batch no. is given. Substance identity and composition is reliability with restrictions. No Statement from company owner is received on substance identity and composition mentioned in study report).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- Principles other than OECD Guideline:
- Only raw data were reported.
- Very limited reported study.
- Not always a 14 day observation period. - GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium sulphate
- EC Number:
- 233-135-0
- EC Name:
- Aluminium sulphate
- Cas Number:
- 10043-01-3
- Molecular formula:
- Al.3/2H2O4S
- IUPAC Name:
- Aluminium sulphate
- Details on test material:
- - Name of test material (as cited in study report): aluminum sulfate solution, iron free
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: water or Tween with water
- Doses:
- 2000, 4640 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 females (2000 mg/kg bw)
5 males (4640 mg/kg bw)
5 males and 5 females (5000 mg/kg bw) - Control animals:
- other: not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: daily; weighing: at least once
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic abnormalities (section) - Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: 5000 mg/kg bw: mild depression, ruffled fur and mild lacrimations in 5/5 male animals. All appear normal 3 days after treatment. 5000 mg/kg bw: mild depression in 5/5 female animals. However, all appear normal at the same day of treatment.
- Gross pathology:
- Necropsy examination revealed no substance-related findings.
- Other findings:
- See table below.
Any other information on results incl. tables
Date |
Sex |
Dose (mg/kg) |
Vehicle |
# deaths |
Total # animals |
Clinical observations |
Necropsy observations |
11August1976 |
M |
4640 |
Tween 80 + H2O |
0 |
5 |
Appear normal |
|
8July1976 |
M |
5000 |
H2O |
0 |
5 |
Day 1: - Ruffled fur - Mild lacrimations Day 2 + 3: - Mild depression Following days: - Appear normal |
No gross abnormalities |
|
|
|
|
|
|
|
|
18June1976 |
F |
2000 |
Tween 80 + H2O |
0 |
5 |
Appear normal |
|
13July1976 |
F |
5000 |
H2O |
0 |
5 |
Day 1: - Mild depression Following days: - Appear normal |
No gross abnormalities |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified - Executive summary:
This study was performed with some equivalence to OECD Guideline 401 (Acute Oral Toxicity). However, not according to GLP standards.
The test material was evaluated for its acute oral toxicity potential in rats when administered as oral doses at levels of 2000 mg/kg bw in Tween/water to females, 4640 mg/kg bw in Tween/water to males and 5000 mg/kg bw in water to males and females. No mortality occurred. No clinical changes were observed at 2000 and 4640 mg/kg dose levels. At 5000 mg/kg clinical signs of toxicity included mild depression and ruffled fur. All appeared normal after 1 (females) or 3 males) days.
The acute oral median lethal dose to rats of aluminum sulphate was found to be greater than 5000 mg/kg bodyweight for males and females. Therefore the test material is not classified, according to OECD-GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.