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EC number: 914-920-3 | CAS number: -
Flarend et al. (2001)studied the uptake of aluminium from aluminium chlorohydrate-containing antiperspirant using26Al as a tracer. The study was carried out using two human volunteer subjects, one male and one female. 0.4 mL of 21%26Al-ACH solution was applied to an area 3”x4” in the left axilla of the two volunteers. Application was done using a pre-soaked (deionized water) cotton swab. The area was allowed to air dry afterwards. After the ACH had been applied and left to dry, the area was occluded with a bandage with adhesive edges that did not contact the area of ACH application. Each morning for the next 6 days strips of tape were applied to the axilla and then stripped away, the area gently washed with towelettes–and the bandage, tape strippings and towelettes sealed in freezer bags and stored in a refrigerator until analysis. The female subject developed a mild irritation to the bandage adhesive that required cessation of their use after 4 days. Blood samples were taken by venipuncture before ACH application (0 hours) and also at 6 and 14 hours post-application; then on days 1, 2, 3, 4, 5, 6, 7, 9, 11, 14, 18, 24, 32, 42 and 53 after application. Twenty-four hour urine samples were collected daily for the first 11 days after application; then from days 13 to 14, 17 to 18, 23 to 24, 31 to 32, 41 to 42, and 52 to 53. The samples were preserved using 10-20% (by volume) conc. HNO3.26Al in the samples was determined by accelerator mass spectrometry. ICP-MS was used to measure Al levels in a subset of urine samples to ensure that the amount of Al in the urine would not influence the results from the AMS analyses. Based on the amounts of26Al in the bandages, tapes and towelettes, 48% of the Al applied to the underarm of the male subject was recovered from the skin surface in 6 days; 31% was recovered in 4 days in the female subject. Levels of26Al in the blood showed a clear increase after the application of ACH and26Al could still be detected 15 days after application. Although26Al could be detected in the blood, the levels were too low for reliable estimation of the % absorbed. Results showed that 0.0082% of the estimated absorbed26Al was eliminated in the urine of the male subject and 0.016% in the urine of the female subject. In conclusion, aluminium is absorbed into the systemic circulation on single occluded application of aluminium chlorohydrate to underarms. Based on urine measurements, 0.012% of the applied aluminium was absorbed showing that aluminium does not cross the dermal barrier effectively.
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