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EC number: 914-920-3 | CAS number: -
Nominal concentration (mg/L)
A study sponsored by the Aluminium Salts Subgroup of the Cefic Incopa Sector Group was performed at the Fraunhofer-Institute for Molecular Biology and Applied Ecology to evaluate the acute toxicity of aluminium sulphate-14-hydrate to Daphnia magna relevant for an accidental exposure. Aluminium sulphate-14-hydrate was tested at nominal concentrations of 10, 20, 40, 80, and 160 mg/L under static conditions for 48 hours. Test water was reconstituted water according to OECD TG 203, without pH adjustment. The initially measured concentrations based on total aluminium differed by less than 20 % from nominal values. The mean measured dissolved aluminium concentrations strongly depended on pH which was influenced by the test item. The EC50 of the test item was determined to be - 48 mg test item /L (95 % confidence limits: 41 – 56 mg/L). The concentration-effect relationship for the test item integrates the enhanced solubility of aluminium at the pH caused by the test item concentration: 48 mg/L of aluminium sulphate-14-hydrate reduced the pH of reconstituted water (OECD 203) to a level which enabled 0.33 mg Al/L to be dissolved, causing 50 % immobility after 48 h.
In the acute immobilisation test with Daphnia, the LOEC was determined to be 750 mg/L ALS to Daphnia magna, The EC50 was determined to be 870 mg/L ALS. No reference test was used, as prescribed by the guideline. The test was performed according to the OECD 202 guideline. Most validity criteria have been met.
measured concentrations appeared to be very pH dependent and reached maximum solubility. therefore the nominal and measured (dissolved) concentration) are very diffrent. The result therefore is that the NOEC exceeds the water solubility at the tested pH's.
A study sponsored by the Aluminium Salts Subgroup of the Cefic Incopa Sector Group was performed at the Fraunhofer-Institute for Molecular Biology and Applied Ecology to evaluate the acute toxicity of aluminium sulphate-14-hydrate to Daphnia magna. Aluminium sulphate-14-hydrate was tested at nominal concentrations of 10, 20, 40, 80, and 160 mg/L under semi-static conditions (daily renewal of the test medium) for 48 hours. Test water was reconstituted water according to OECD TG 203, with pH adjusted to 7.5 at each renewal. The mean measured concentrations based on total aluminium differed by less than 20 % from nominal values for all concentrations except the lowest one. The concentrations of dissolved aluminium were measured between 0.1 and 0.2 mg/L, irrespective of the applied amount of total aluminium. Up to the highest test concentration, no immobility could be observed after 48 h. Thus, the NOEC of aluminium sulphate-14-hydrate under the described study conditions was determined as follows:
NOEC ≥ 160 mg aluminium sulphate-14-hydrate / L and exceed the water solubility at the tested pH levels.
No reliable studies on the acute toxicity of reaction mass of aluminium hydroxide and aluminium nitrate and aluminium sulphate to invertebrates are available.Therefore, a weight of evidence approach is applied and data are read-across to various aluminium compounds based on an analogue approach.
Two guideline studies with Daphnia magna are available (Schäfers, 2003) for aluminium sulfate. One test was static without pH adjustment. In this test an EC50 was found of 0.33 mg/l (dissolved Al) at a pH of approximately 6.5 -7.5. The second test was semi-static with pH adjustment. The test substance concentrations were in a range of 10 to 160 mg/l (nominal), this resulted in dissolved aluminum concentrations of 0.107 to 0.176 mg/l. The pH was between 7.5 and 8.0. No effects were found in this test, therefore, EC50 is greater than 0.176 mg/l (dissolved Al and > 160 mg/L nominal), which was the maximum soluble concentration under the test conditions.
Further data from non-guideline studies (RL2) conducted Kimball (1978), Biesinger & Christensen (1972), and Martin & Holdich (1986) are available. All these studies report LC50/EC50 values based on total Al well above 1 mg/L, ranging from 3.9 to 38.2 mg/L.
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