1-Butanone, 2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(4-morpholinyl)phenyl]-

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 841449/EWG, C.5 (Mod. Sturm)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

119313-12-1

EC Number:

601-598-1

Cas Number:

119313-12-1

IUPAC Name:

119313-12-1

Constituent 2

Reference substance name:

2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone

EC Number:

404-360-3

EC Name:

2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone

IUPAC Name:

2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- Molecular formula (if other than submission substance):C23H30N2O2
- Molecular weight (if other than submission substance):366.5
- Smiles notation (if other than submission substance):CCC(CC1=CC=CC=C1)(C(=O)C2=CC=C(C=C2)N3CCOCC3)N(C)C
- InChl (if other than submission substance):1S/C23H30N2O2/c1-4-23(24(2)3,18-19-8-6-5-7-9-19)22(26)20-10-12-21(13-11-20)25-14-16-27-17-15-25/h5-13H,4,14-18H2,1-3H3
- Physical state: Powder
- Analytical purity: >99%

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point:113.2 °C
- Boiling point:400 °C
- density: 1.21
- Vapour pressure: 0.01 Pa at 95 °C
- Water solubility (under test conditions): 5.9 mg/L
- log Pow: 2.91
- pH dependance on stability: Less than 10% hydrolysis was observed after 5 days at 50 C at pH4 and pH7.


OTHER PROPERTIES (if relevant for this endpoint)
- Adsorption characteristics: log Koc= 4.69
- Toxicity to microorganisms: EC50/LC50= 5.9 mg/L
IC50 Concentration in mg/l: 30 minutes: >5.9 NOEC (mg/l): 30 minutes: 5.9A supersaturated solution of the substance was generated using 50mg in 500ml. This is well in excess of solubility and would have resulted in a maximum dissolved eoncentration of 5.9mg/l (but is likely ,to have been considerably lower by comparison with the concentrations achieved in the other tests carried out on the substance). No effects were seen on respiration of the sludge at the maximum attainable concentration.

Results and discussion

% Degradation

Parameter:

% degradation (DOC removal)

Value:

3

Sampling time:

28 d

BOD5 / COD results

BOD5 / COD

Parameter:

COD

Value:

2.1 g O2/g test mat.

Results with reference substance:

Points of degradation plot (reference substance):
45.3 % degradation after 4 d
69.6 % degradation after 7 d
78.3 % degradation after 11 d
81.1 % degradation after 15 d
86.3 % degradation after 18 d
84.9 % degradation after 22 d
84.3 % degradation after 27 d
87.2 % degradation after 28 d