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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

(-)-Phenylacetylcarbinol was tested for mutagenicity in bacteria according to the Ames II Assay which is the liquid version of the classical Ames test using microwell plates. The Ames II assay is done in contrast to the classical Ames in microwell plates using a modified fluctuation test protocol. Besides the traditional tester strain TA 98 six his mutant strains TA 7001 - TA 7006 (Ames II tester strains) are used to detect base-pair substitutions. The test was carried out based on the description of Gee et al. (Mut Res 412: 115-130, 1998) and on the "Users Manual" prepared by XENOMETRIX, Inc., Colorado, USA.

The test item did not lead to an increase in the number of revertant wells either with or without S-9 mix.

Thus, under the experimental conditions chosen here, (-)-Phenylacetylcarbinol is not a mutagenic agent in the Ames II Assay.


Short description of key information:
in vitro: AMES II Test: negative (BASF AG, 2001, 44M0254/014061)
No further data available

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Dangerous Substance Directive (67/548/EEC)

The available study is considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for mutagenicity under Directive 67/548/EEC.

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for mutagenicity under CLP Regulation (EC) No. 1272/2008.