Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-285-4 | CAS number: 1798-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF Test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (R)-1-hydroxy-1-phenylacetone
- EC Number:
- 217-285-4
- EC Name:
- (R)-1-hydroxy-1-phenylacetone
- Cas Number:
- 1798-60-3
- Molecular formula:
- C9H10O2
- IUPAC Name:
- (1R)-1-hydroxy-1-phenylpropan-2-one
- Details on test material:
- Name of test material: (-)-Phenylacetylcarbinol
- Physical state: liquid
- Analytical purity: 67.4 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Willi Gassner, Sulzfeld, Germany
- Age at study initiation: 4 weeks
- Weight at study initiation: 28 g (mean weight males), 22 g (mean weight females)
- Fasting period before study: 16 hrs
- Housing: 5 animals per cage,Macrolon cages
- Diet: Herilan, MRH-Haltung (H. Eggersmann KG, Rinteln), ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20- 26
- Humidity (%): 45- 75
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- (0.5 % aqueous solution)
- Details on exposure:
- VEHICLE
-Concentration in vehicle: 7 % for high dose, 2 % for low dose
- Justification of choice of vehicle: formulation according to the physiological medium
- Amount of vehicle: 10 mL/kg bw - Doses:
- 200, 700 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: before substance application, betweeen 2- 4 days, day 7, day 13 after substance application
- Frequency of observations: immediately after substance application (< 15 min), 15, 30, 60, 120, 240, 300 min after substance application then once per workday check for clinical symptoms. Twice per workday and once on other days check for dead and moribund animals.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: > 200 (1% significance level); < 700 (5 % signficance level)
- Mortality:
- 200 mg/kg bw: 0/5 females and 0/5 males died
700 mg/kg bw: 4/5 males (at 1hr and 2 days post-dose) and 5/5 females (at 7 and 14 days post-dose) died - Clinical signs:
- 700 mg/kg bw: dyspnoea, apathy, abnormal position, staggering, atony, unusual pain reflex, unusual corneal reflex, narcotic state, spastic walking, scrubby fur, ptosis, bad general state
200 mg/kg bw: dyspnoea, apathy, staggering, bad general state - Body weight:
- 200 mg/kg bw: body weight gain were within normal ranges
700 mg/kg bw: the one male that survived showed no body weight gain during the first 7 days; afterwards normal body weight increased until test ending; for the females, reduction in body weight was notice during the first 7 days. - Gross pathology:
- dead animals:
no diagnosis possible
sacrificed animals:
no intraabdominal substance precipitation or conglutination
Any other information on results incl. tables
Table 1. Table of acute toxicity, intraperitoneal route |
|||
|
|
|
|
Dose |
Toxicological results* |
Time of death |
Mortality (%) |
Males |
|||
200 |
0/5 |
-- |
0 |
700 |
4/5 |
1 hr, day 2 |
80 |
Females |
|||
200 |
0/5 |
-- |
0 |
700 |
5/5 |
day 7, day 14 |
100 |
* first number = number of dead animals, second number = number of animals used
|
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.