Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally acceptable scientific principles (mainly local effects were studied; no dosis reported)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
Butan-1-ol was applied to rabbit skin under occlusive conditions for 12* 5 h. Mainly local effects were studied.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Butan-1-ol
EC Number:
200-751-6
EC Name:
Butan-1-ol
Cas Number:
71-36-3
IUPAC Name:
butan-1-ol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of treatment / exposure:
21 d
Frequency of treatment:
12 * 5 h within 21 d
Doses / concentrations
Remarks:
Doses / Concentrations:

Basis:
no data
No. of animals per sex per dose:
no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Drying of the skin was reported and on continuous exposure, cracking, furrowing and exfoliation of the epidermis.

No systemical toxicity noted.

Applicant's summary and conclusion