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EC number: 940-673-6 | CAS number: 1391764-61-6
number of lymph nodes
DPM per lymph nodeb)
1 = Control Group (PG)
2-4= Test Groups (K-36)
5 = Control Group for Positive Control (acetone/olive oil (4+1, v/v))
6 = Positive Control Group (Alpha-Hexylcinnamaldehyde; HCA)
a) = The mean value was taken from the figures BG I and BG II
b) = Since the lymph nodes of the animals of a dose group were pooled, DPM/node was determined by dividing the measured value by the number of lymph nodes pooled
The EC3 value could not be calculated, since all S.I.´s are below the threshold value of 3.
In the study the test item K-36 formulated in PG was assessed for its possible skin sensitising
For this purpose a local lymph node assay was performed using test item concentrations of 2.5, 5
and 10%. The highest concentration tested was the highest concentration that could be technically
achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed in the
The animals did not show any signs of systemic toxicity during the course of the study and no
cases of mortality were observed. The observation of skin irritation was not possible due to
inherent color of the test item.
On day 3 and 4, the animals treated with positive control substance showed an erythema of the
ear skin (Score 1).
In the groups treated with a test item concentration of 2.5 and 10%, a statistically significant
increase (p < 0.05) in ear weight was observed in comparison to the values of the vehicle control
group. However, this increase was considered to be not biologically relevant.
In this study Stimulation Indices (S.I.) of 1.66, 1.39 and 1.72 were determined with the test item
at concentrations of 2.5, 5 and 10% formulated in PG, respectively.
The test item K-36 was not a skin sensitiser under the test conditions of this study.
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