Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from to
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: calculated with the Antoine equation
Temp.:
25 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: calculated with the Antoine equation
Temp.:
50 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: calculated with the Antoine equation
Transition / decomposition
Transition / decomposition:
no

Any other information on results incl. tables

Thermal stability:

The DSC-measurement showed no endothermic or exothermic effects up to 300 °C (final measurement temperature).

Vapour pressure balance (effusion method):

Table 1: Measured vapour pressures and corresponding temperatures

Temperature (°C)

Vapour pressure (hPa)

70

6.7 x 10-6

80

- (*)

90

- (*)

100

- (*)

110

- (*)

120

- (*)

130

- (*)

(*) No calculation of the vapour was pressure possible because no weight decrease could be detected.

 

The vapour pressure in the temperature range of 70 - 130°C was below the lower detection limit of 10-5 hPa.

The vapour pressure of the test item at 20, 25 and 50 °C was estimated. According to the Antoine equation, the vapour pressure can be calculated according to:

log ( p ) = A + B/( C + T ), where

P = Vapour pressure in hPa

T = Temperature in °C

A, B, C = Antoine constants

For a conservative estimation of the vapour pressure of the test item at 20, 25 and 50 °C, a value of -5000 for constant B and a value of 273.15 for constant C, respectively, were used.

The last data point of the measurement at 70.0 °C was used as the starting point for the calculation. The measured vapour pressure at 70.0 °C was below 10-5 hPa. For a conservative estimation, it was assumed that the vapour pressure at 70.0 °C is equal to the lower detection limit of the vapour pressure balance (10-5 hPa).

Based on this assumption, the constant A of the Antoine equation was calculated:

A = log ( p ) - B/( C + T ) = log ( 10-5 ) – (-5000)/( 273.15 + 70 ) = 9.57

 

Subsequently, the vapour pressure at 20, 25 and 50 °C can be calculated with the Antoine equation:

Table 2: Calculated vapour pressure at 20, 25 and 50 °C

T (°C)

p (hPa)

p (Pa)

20

< 3.3 x 10-8

< 3.3 x 10-6

25

< 6.3 x 10-8

< 6.3 x 10-6

50

< 1.3 x 10-6

< 1.3 x 10-4

This is a conservative estimation of the vapour pressure of the test item for the listed temperatures. The true vapour pressure is most likely to be even much lower than this value derived from the detection limit. Due to a conservative approach the vapour pressure is rounded up to the next order of magnitude.

Applicant's summary and conclusion

Conclusions:
The extrapolated vapour pressure of K-36 are < 3.3 x 10-8 hPa, < 6.3 x 10-8 hPa and < 1.3 x 10-6 hPa respectively at 20, 25 and 50°C.
Executive summary:

The vapour pressure of K-36 was assessed using the balance method, according to EU Guideline A.4 and OECD Guideline 104.

The extrapolated vapour pressure of K-36 are < 3.3 x 10-8 hPa, < 6.3 x 10-8 hPa and < 1.3 x 10-6 hPa respectively at 20, 25 and 50°C.