Aluminium sulphate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, sufficiently documented, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Acute dermal LD50 in the rabbit of ZEOLEX 23A. HRC, HRC No 783-225,

Author:

J.M. Huber Corp.

Year:

1979

Bibliographic source:

J.M. Huber Corp.: Acute dermal LD50 in the rabbit of ZEOLEX 23A. HRC, HRC No 783-225, 27 April 1978 (also part of LSRO 1979)

Reference 2

Reference Type:

review article or handbook

Title:

Evaluation of the health aspects of certain silicates as food ingredients

Author:

LSRO (Life Sciences Research Office) FASEB:

Year:

1979

Bibliographic source:

LSRO (Life Sciences Research Office)/FASEB: Evaluation of the health aspects of certain silicates as food ingredients. NTIS PB 301402, 1979

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Principles of method if other than guideline:

Method: the substance was mixed with distilled water to form an aqueous paste. Application to the intact and abradet skin.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Silicic acid, aluminum sodium salt

EC Number:

215-684-8

EC Name:

Silicic acid, aluminum sodium salt

Cas Number:

1344-00-9

Test material form:

solid: compact

Details on test material:

TS-Freetext: ZEOLEX 23A, Silicic acid, aluminum sodium salt

-Name of test material : Silicic acid, aluminum sodium salt
- CAS mumber: 1344-00-9
- EC number: 215-684-8
- Generic empiricalformula: : nSiO2 • mAl203• xNa20
- Molecular weight : 60.08g/mol (SiO2)
- Substance type:inorganic
- Physical state: solid
-Colour : White
-Odour : Odourless
- Density: 2.1 g/cm3 at 20 °C
- Melting point: 1700 °C
- Boiling point: 1 >>1700 °C: not relevant for normal and intended use
- Solubility in water: 68-79 mg/l at 20 °C - Tradenames: Sipernat, Alusil ET, Zeolex, Hydrex, Huberfil, Durabrite, Zeocopy, Tixolex, Rhodoxane

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Details on test animals or test system and environmental conditions:

The TS was applied as paste to the intact and abraded skin.
4 animals per dose.
Occlusive exposure for 24 h. Post-treatment observation 14 d.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Duration of exposure:

24 h

Doses:

2000, 3000, 4000, and 5000 mg/kg as aqueous paste

No. of animals per sex per dose:

16

Control animals:

yes

Results and discussion

Preliminary study:

Occlusive exposure for 24 h. Post-treatment observation 14 d.
No pathological findings. Dermal reactions were limited to
slight erythema and edema.

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: The TS was applied as paste to the intact and abraded skin. 4 animals per dose. Occlusive exposure for 24 h. Post-treatment observation 14 d. No pathological findings. Dermal reactions were limited to slight erythema and edema.

Mortality:

No pathological findings. Dermal reactions were limited to
slight erythema and edema.

Any other information on results incl. tables

No pathological findings. Dermal reactions were limited to
slight erythema and edema.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

No pathological findings. Dermal reactions were limited to slight erythema and edema.