Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 446-420-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The key studies (Hooiveld, 2003) and (Hooiveld, 2003) report that the registered substance is not irritating to the skin or eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The key study for skin irritation (Hooiveld, 2003) was conducted according to the OECD 404 guideline under GLP conditions. The study was perfomed on male New Zealand White rabbits using watery ethanol (50%) in a 4 hour semi-occlusive exposure. After four hours of exposure very slight oedema was noted in one animal however this was reversed at the 24 hour observation. As this was the only sign of irritation it was concluded that the registered substance does not cause irritation.
The study was awarded the reliability score of 1 according to the criteria of Klimisch et al (1997).
The key study for eye irritation (Hooiveld, 2003) was conducted according to the OECD 405 guideline under GLP conditions. The study was performed on male New Zealand White rabbits. Approximately 24.9 mg of the unchanged registered substance was applied to the conjunctival sac of one eye with the untreated eye serving as a control. The registered substance caused slight redness and discharge in the conjunctivae, however no other signs of irritation were noted. No significant irritation lasted for 24 hours or more. Based upon these results the registered substance was considered not to be irritating to the eye.
The study was awarded the reliability score of 1 according to the criteria of Klimisch et al (1997).
Justification for classification or non-classification
Based upon the key information for skin and eye irritation the registered substance does not meet the criteria for classification as an irritant to either the skin or eye according to EC Regulation 1272/2008 and directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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